The Lyme Disease Network
Medical / Scientific Abstract

Title:In vitro susceptibilities of Borrelia burgdorferi to five oral cephalosporins and ceftriaxone.
Authors:Agger WA, Callister SM, Jobe DA
Source:Antimicrob Agents Chemother 1992 Aug;36(8):1788-90
Organization:Microbiology Research Laboratory Gundersen Medical Foundation Las Crosse Wisconsin 54601.

We determined the in vitro susceptibilities of eight Borrelia burgdorferi isolates to five oral cephalosporins. MICs for B. burgdorferi 297 were 23 micrograms/ml (cephalexin), 45 micrograms/ml (cefadroxil), 91 micrograms/ml (cefaclor), 0.13 microgram/ml (cefuroxime), 0.8 microgram/ml (cefixime), and 0.02 microgram/ml (ceftriaxone). When B. burgdorferi isolates were exposed to concentrations twice the MIC of cefuroxime, cefixime, or ceftriaxone, at least 72 h of incubation was required to kill 99% of the organisms.

Borrelia burgdorferi, DE, Ceftriaxone, PD, Cephalosporins, PD, Half-Life, Human, Lyme Disease, MI, Support, Non-U.S. Gov't, Medline File

Language: French

Unique ID: 93037309

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