The Lyme Disease Network
Medical / Scientific Abstract
|Title:||Animal models of Lyme disease: pathogenesis and immunoprophylaxis.|
|Authors:||Philipp MT, Johnson BJ|
|Source:||Trends Microbiol 1994 Nov;2(11):431-7|
|Organization:||Tulane University Medical Center, Tulane Regional Primate Research Center, Covington, LA 70433.|
Valuable insights into the pathogenesis and immunoprophylaxis of Lyme disease are beginning to emerge from studies in animal models. This review highlights two animal models: the mouse, which has allowed us to investigate the role of both the immune response and spirochete phenotype in determining the outcome of the disease; and the Rhesus monkey, which manifests signs of nerve involvement, in addition to showing erythema migrans and arthritis.
Animal, Bacterial Vaccines, ADMINISTRATION & DOSAGE, Borrelia burgdorferi, PATHOGENICITY, Consumer Product Safety, Disease Models, Animal, Human, Lyme Disease, IMMUNOLOGY, MICROBIOLOGY, PATHOLOGY, PREVENTION &, CONTROL, Macaca mulatta, Mice, Mice, Inbred C3H, Treatment Outcome
Unique ID: 95171065
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