The Lyme Disease Network
Medical / Scientific Abstract

Title:Animal models of Lyme disease: pathogenesis and immunoprophylaxis.
Authors:Philipp MT, Johnson BJ
Source:Trends Microbiol 1994 Nov;2(11):431-7
Organization:Tulane University Medical Center, Tulane Regional Primate Research Center, Covington, LA 70433.

Valuable insights into the pathogenesis and immunoprophylaxis of Lyme disease are beginning to emerge from studies in animal models. This review highlights two animal models: the mouse, which has allowed us to investigate the role of both the immune response and spirochete phenotype in determining the outcome of the disease; and the Rhesus monkey, which manifests signs of nerve involvement, in addition to showing erythema migrans and arthritis.

Animal, Bacterial Vaccines, ADMINISTRATION & DOSAGE, Borrelia burgdorferi, PATHOGENICITY, Consumer Product Safety, Disease Models, Animal, Human, Lyme Disease, IMMUNOLOGY, MICROBIOLOGY, PATHOLOGY, PREVENTION &, CONTROL, Macaca mulatta, Mice, Mice, Inbred C3H, Treatment Outcome

Language: Eng

Unique ID: 95171065

The Lyme Disease Network of NJ, Inc.
43 Winton Road
East Brunswick, NJ 08816