The Lyme Disease Network
Medical / Scientific Abstract

Title:Detection of Borrelia burgdorferi antigens in cerebrospinal fluid.
Authors:Coyle PK, Deng Z, Schutzer SE, Belman AL, Benach J, Krupp LB, Luft B
Source:Neurology 1993 Jun;43(6):1093-8
Organization:Department of Neurology, SUNY at Stony Brook 11794.

We examined CSF for Borrelia burgdorferi antigens using antigen-capture ELISA and Western (immuno) blot. Antigen-capture ELISA was positive in 38 of 77 (49%) CSF samples obtained from neurologic patients with presumed B burgdorferi infection, compared with one of 34 (3%) CSF samples obtained from other neurologic disease controls who came from a region endemic for Lyme disease. Western immunoblot was positive for B burgdorferi antigens in 12 of 22 (55%) CSF samples from the B burgdorferi infected groups, compared with none of 11 CSF samples from the control group. CSF antigen detection should prove helpful in evaluating patients for suspected neurologic Lyme disease.

Adolescence, Adult, Aged, Aged, 80 and over, Antigens, Bacterial, CEREBROSPINAL FLUID, Blotting, Western, Borrelia burgdorferi, IMMUNOLOGY, Child, Child, Preschool, Enzyme-Linked Immunosorbent Assay, Female, Human, Lyme Disease, CEREBROSPINAL FLUID, Male, Middle Age, Sensitivity and Specificity, Support, Non-U.S. Gov't, Support, U.S. Gov't, P.H.S.

Language: Eng

Unique ID: 94224329

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