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Volume: 5
Issue: 01
Date: 27-Jan-97


Table of Contents:

I.    LYMENET: 10th Annual International Conference on Lyme
      Disease & other Tick-borne disorders
II.   LYMENET: New Video Available Detailing LD Issues
III.  REV CLIN ESP: Evaluation of methods of tick removal in
      human ixodidiasis
IV.   SCAND J INFECT DIS: Antibiotics and increased temperature
      against Borrelia burgdorferi in vitro
V.    About The LymeNet Newsletter


Newsletter:

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*                  The National Lyme Disease Network                  *
*                         LymeNet Newsletter                          *
***********************************************************************


IDX#                Volume 5 / Number 01 / 24-JAN-97
IDX#                            INDEX
IDX#
IDX#  I.    LYMENET: 10th Annual International Conference on Lyme
IDX#        Disease & other Tick-borne disorders
IDX#  II.   LYMENET: New Video Available Detailing LD Issues
IDX#  III.  REV CLIN ESP: Evaluation of methods of tick removal in
IDX#        human ixodidiasis
IDX#  IV.   SCAND J INFECT DIS: Antibiotics and increased temperature
IDX#        against Borrelia burgdorferi in vitro
IDX#  V.    About The LymeNet Newsletter
IDX#



I.    LYMENET: 10th Annual International Conference on Lyme Disease
     & other Tick-borne disorders
-------------------------------------------------------------------
Sender: Tom Forschner <ldftf@aol.com>
Date: January 22, 1997


       10th Annual International Conference on Lyme Disease
                  & other Tick-borne disorders


PLACE:
National Institutes of Health, Clinical Center
Bethesda, Maryland


PROGRAM TOPICS:

Biology and Pathogenesis  
* Molecular Biology and Genetics
* Structure-Function Relationships
* Host Immune Response


Prevention
* Ecology
* Entomology
* Animal Models
* Vaccines


Patient Management
* Clinical Manifestations
* Clinical and Laboratory Diagnosis
* Early Disseminated Disease Management
* Late Disseminated Disease Management
* Chronic Disease Management


General Discussion of Hot Topics  

Poster Presentations

Public Forum

Workshop on Scientific Manuscript Preparation
(writing your scientific data for publication)


PROGRAM COMMITTEE

James Miller, Ph.d. - Conference Chairman
Professor, UCLA School of Medicine
Benjamin Luft, MD - Conference Co-Chairman
Chief of Medicine, SUNY School of Medicine


Basic Science
James Miller, Ph.d. - Chairman, UCLA School of Medicine
Mario Phillip, Ph.d. - Co-Chairman, Tulane University
Steven Barthold, Ph.d. - Yale University
David Dorward, Ph.d. - National Institutes of Health
Janis Weis, Ph.d. - University of Utah
Edward Bolser, Ph.d. - SUNY School of Medicine


Clinical Sessions
Benjamin Luft, MD - Chairman, SUNY, School of Medicine
Sam Donta, MD - Co-Chairman, Boston Univ. Medical Ctr
Patricia Coyle, MD - SUNY School of Medicine
Kenneth Liegner, MD - Northern Westchester Hospital
Gerold Stanek, MD - Hygiene -Institut der Universitaet
Alan Barbour, MD - University of California, Irvine


Poster Session
Ron Schell, Ph.d.  - Chairman, Univ. of Wisc. Medical School
Charles Pavia, Ph.d. - Co-Chairmen, NY Medical College


Public Forum
Joseph Burrascano, MD - Internist, Southamptom Hospital
Julie Rawlings, MPH - Texas Department of Health


Reception
Claude Garon, Ph.d. - National Institutes of Health, RML
Ken Liegner, MD - Northern Westchester Hospital


Conference Coordinating Committee
Betty Bosler, MPH - SUNY School of Medicine
Tom Forschner, MBA, CPA - Executive Director LDF
Karen V-Forschner, MBA -Chair  LDF


--

CONFERNECE REGISTRATION FORM:

o MD     o DO     o DVM     o PhD     o DDS     o MPH  
o RPh     o RN     o Mr.        o Mrs.     o Ms.      o ____



Last name_________________________________________

First name_________________________________________

Title/position_______________________________________

Institution_________________________________________

Address __________________________________________

       __________________________________________

City__________________State________Zip_____________

phone_______________________fax________________________

e-mail______________  

o Enroll me in the Workshop (To attend, you must submit a completed  
scientific manuscript by 4/2/97)


Fees   (CME's a separate fee, to be determined)
Fees include attendance at scientific sessions, refreshments,
book of proceedings, and the reception.


o $200 (by 4/1/97)   o $300 (4/ 2-26 /97)   o $350 (after 4/26/97)
o $150  Poster presenters      
o $  35  Reception only  (non-registrants)


______ Total Amount Enclosed


Payment Method

o  Check enclosed (payable to "Lyme Disease Foundation")
o  Credit Card Charge
  o  Master Card    o  Visa     o  American Express  


  Card #________________________________________

  Expiration date_____/_____

  Cardholder's signature:___________________________


Payment must accompany registration and must be in U.S. funds.  
Mail or fax registration to:


LDF, One Financial Plaza, Hartford, CT 06103
(860) 525-2000  fax (860) 525-8425
EMAIL LDFTF@AOL.COM


Written notice of cancellation must be received by the LDF no later
than 4/1/97.



=====*=====


II.   LYMENET: New Video Available Detailing LD Issues
------------------------------------------------------
Sender: Stephen Zimmer <szimmer105@aol.com>
       Fax: (606)-257-8940
Date:  December 11, 1996


Lexington, KY -- The issues involving Lyme Disease, one of the fastest
growing and most complicated diseases in the country, are exposed in a
new hour long video sponsored by the Lyme Awareness Fund and produced
by Diatheke Eirene, LTD.  The video, whose proceeds go to fund Lyme
Disease research, is an in-depth look at a disease that is well-
publicized in the northeastern parts of the United States.  


Lyme Disease, primarily conveyed through the bite of a tick, is now
diagnosed throughout the continental United States and is becoming an
increasing concern for people (and their pets),  not just those who
spend a significant amount of time in nature settings.  Anywhere that
a tick can go, from the backyard of a house to a ride on the back of
the family's cat, the disease can follow.


With expensive treatments and a known difficulty of diagnosis, as its
symptoms simulate other diseases, Lyme Disease is also becoming a point
of contention between insurance groups and patient advocacy groups.  
"Time For Truth" looks into a number of these stories through the eyes
of the people affected directly by the conflicts.


The video also features expert insights from researchers, clinical
physicians, and psychiatrists, as well as from a professional patient
advocate.  The video also features a guest appearance by Denise Lang,
whose book Coping with Lyme Disease is the biggest selling book on the
topic of Lyme Disease.  Popular singer Gloria Estefan contributed to
the video through her hit song, "Always Tomorrow".


As infected ticks continue to increase in number and range, awareness
of Lyme Disease is quickly becoming a vital necessity.  Precautions
can be taken by those who spend a significant amount of time in
nature, a group that is slightly more at risk of exposure, and
treatments are available and generally effective if the disease is
diagnosed in its early stages.


Knowledge can make a difference, from possible  infection to
treatment, and "Time For Truth" has been produced to assist in that  
educational process.



=====*=====


III.  REV CLIN ESP: Evaluation of methods of tick removal in human
     ixodidiasis
------------------------------------------------------------------
AUTHORS: Oteo JA, Martinez de Artola V, Gomez-Cadinanos R, Casas JM
        Blanco JR, Rosel L
ORGANIZATION: Servicio de Medicina Interna, Hospital de La Rioja,
             Logrono.
REFERENCE: Rev Clin Esp 1996 Sep;196(9):584-7
URL: http://search.lymenet.org/Abstracts/97091472.htm
ABSTRACT:


BACKGROUND: There are two questions regarding tick transmitted
diseases (Ixodidae) not sufficiently elucidated: How to remove the
arthropod? and: should antibiotic prophylaxis be administered after
the bite?
SUBJECTS AND METHODS: From June 1st, 1991, to December, 31, 1992,
all patients who were attended at La Rioja Hospital relating immediate
bite or tick bite within the 48 hours before were prospectively
studied. In all those patients an epidemiological inquiry was
obtained, which included, apart from personal data and risk factors
for tick bites, how arthropods had been removed, health exam and
blood drawn for serological study for Borrelia burgdorferi and
Rickettsia conorii. The protocol was repeated at one, two, four and
six months after the bite. The removal method used at the Hospital
was by pulling with fine tweezers and later disinfection with iodine
povidone.
RESULTS: Out of a total of 52 individuals who complied with the
established criteria, only 41 ended the follow-up. A 63.4 percent of

patients experienced some type of complication, including 3 cases of
LB (erythema migrans). With regard to the type of removal method and
the development of complications, only three patients who had ticks
pulled with tweezers experienced complications compared with 23
patients who used other methods (p = 0.0058). With regard to specific
complications (LB and/or spotted fever) and/or development of B.
burgdorferi or R. conorii infection significant differences were also
observed when tweezers were used for removal of ticks compared with
other tick removal methods (p < 0.05).
CONCLUSION: The removal of ticks with tweezers significantly protects
from the development of complications and infection by tick-borne
microorganisms.  Antibiotic prophylaxis is recommended when the
removal of the arthropod is carried out by using a method other than
the recommended one.



=====*=====


IV.   SCAND J INFECT DIS: Antibiotics and increased temperature
     against Borrelia burgdorferi in vitro
---------------------------------------------------------------
AUTHORS: Reisinger E, Wendelin I, Gasser R, Halwachs G
        Wilders-Truschnig M, Krejs G
ORGANIZATION: Department of Medicine, Karl Franzens University,
             Graz, Austria.
REFERENCE: Scand J Infect Dis 1996;28(2):155-7
URL: http://search.lymenet.org/Abstracts/96384594.htm
ABSTRACT:


In 1917, spirochaetal neurosyphilis was treated successfully with
malariotherapy in combination with salvarsan or bismuth.
Malariotherapy for spirochaetal Lyme disease has been discussed, but
the mechanism of an antispirochaetal effect remains unclear.  We
cultured Borrelia burgdorferi at different temperatures, alone and in
combination with antibiotics. Our data demonstrate that growth of
the strains PKo and ATCC 35210 (B31) was impaired at temperatures of
37 degrees C and inhibited at 39 degrees C and 40 degrees C,
respectively.  Strain ATCC 35211, however, grew well up to 39
degrees C but did not multiply at 40 degrees C.  A bactericidal effect
was seen at 41 degrees C for the strains B31 and PKo and at 42
degrees C for all strains. The susceptibility of all strains to
penicillin and ceftriaxone was increased up to 16-fold by an
elevation of temperature from 36 degrees C to 39 degrees C. These in
vitro data suggest that elevated body temperature may be beneficial
during antimicrobial treatment of Lyme disease. This may be

particularly important in tissues where high concentrations of
antibiotics are difficult to achieve.



=====*=====


V.    ABOUT THE LYMENET NEWSLETTER
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         The Lyme Disease Network of New Jersey
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