The Lyme Disease Network
Medical / Scientific Abstract


Title:In vitro susceptibilities of Borrelia burgdorferi to five oral cephalosporins and ceftriaxone.
Authors:Agger WA, Callister SM, Jobe DA
Source:Antimicrob Agents Chemother 1992 Aug;36(8):1788-90
Organization:Microbiology Research Laboratory Gundersen Medical Foundation Las Crosse Wisconsin 54601.

Abstract:
We determined the in vitro susceptibilities of eight Borrelia burgdorferi isolates to five oral cephalosporins. MICs for B. burgdorferi 297 were 23 micrograms/ml (cephalexin), 45 micrograms/ml (cefadroxil), 91 micrograms/ml (cefaclor), 0.13 microgram/ml (cefuroxime), 0.8 microgram/ml (cefixime), and 0.02 microgram/ml (ceftriaxone). When B. burgdorferi isolates were exposed to concentrations twice the MIC of cefuroxime, cefixime, or ceftriaxone, at least 72 h of incubation was required to kill 99% of the organisms.

Keywords:
Borrelia burgdorferi, DE, Ceftriaxone, PD, Cephalosporins, PD, Half-Life, Human, Lyme Disease, MI, Support, Non-U.S. Gov't, Medline File

Language: French

Unique ID: 93037309


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