The Lyme Disease Network
Medical / Scientific Abstract


Title:[Neuroborreliosis in a patient with progressive supranuclear paralysis. An association or the cause?]
Authors:Garcia-Moreno JM, Izquierdo G, Chacon J, Angulo S, Borobio MV
Source:Rev Neurol 1997 Dec;25(148):1919-21
Organization:Departamento de Inmunologia, Hospital Universitario Virgen de la Macarena, Sevilla, Espana. Ayuso@arrakis.es

Abstract:
INTRODUCTION: Many different neurological conditions may be seen in the later stages of Lyme's Disease, such as blindness, epileptic crises, CVA, extrapyramidal disorders, amyotrophic lateral sclerosis, and dementia may be yet another form of presentation of chronic infection due to Borrelia burgdorferi (Bb). Progressive Supranuclear Paralysis (PSP), a disorder of unknown aetiology, considered to be the commonest cause of Parkinsonism-plus, one of the symptoms of which is dementia, has never been mentioned in this type of differential diagnosis. CLINICAL CASE: We present the case of a 78 year old man with sub-acute mental deterioration, Bb positive serology in both plasma and CSF, and with clinical and epidemiological features compatible with Lyme's Disease. Complementary tests were negative. The syndrome corresponded to Lyme's Disease and improved after treatment with ceftriaxona. CONCLUSIONS: We consider aspects of the aetiology of PSP which are still not clear. In our patient, the aetiology seemed to be Bb infection, according to the criteria of the original description of the disease and in view of the neuropathological findings which have shown Bb in the substancia nigra of the mid-brain and the existence of an animal model in which Bb shows a particular tendency to colonize infratentorial structures.

Keywords:
Aged, Antiparkinson Agents, THERAPEUTIC USE, Borrelia burgdorferi, ISOLATION & PURIF, Case Report, Ceftriaxone, THERAPEUTIC USE, Cephalosporins, THERAPEUTIC USE, Dementia, ETIOLOGY, Electroencephalography, English Abstract, Facies, Frontal Lobe, RADIONUCLIDE IMAGING, Human, Lyme Disease, COMPLICATIONS, DRUG THERAPY, Magnetic Resonance Imaging, Male, Parietal Lobe, RADIONUCLIDE IMAGING, Substantia Nigra, MICROBIOLOGY, PATHOLOGY, Supranuclear Palsy, Progressive, DIAGNOSIS, DRUG THERAPY, MICROBIOLOGY, Temporal Lobe, RADIONUCLIDE IMAGING, Tomography, Emission-Computed, Single-Photon

Language: Spa

Unique ID: 98188456


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