The Lyme Disease Network
Medical / Scientific Abstract


Title:Identification of LFA-1 as a candidate autoantigen in treatment-resistant Lyme arthritis [see comments]
Authors:Gross DM, Forsthuber T, Tary-Lehmann M, Etling C, Ito K, Nagy ZA, Field JA, Steere AC, Huber BT
Source:Science 1998 Jul 31;281(5377):703-6
Organization:Department of Pathology, Tufts University, Boston, MA 02111 USA.

Abstract:
Treatment-resistant Lyme arthritis is associated with immune reactivity to outer surface protein A (OspA) of Borrelia burgdorferi, the agent of Lyme disease, and the major histocompatibility complex class II allele DRB1*0401. The immunodominant epitope of OspA for T helper cells was identified. A homology search revealed a peptide from human leukocyte function-associated antigen-1 (hLFA-1) as a candidate autoantigen. Individuals with treatment-resistant Lyme arthritis, but not other forms of arthritis, generated responses to OspA, hLFA-1, and their highly related peptide epitopes. Identification of the initiating bacterial antigen and a cross-reactive autoantigen may provide a model for development of autoimmune disease.

Keywords:
Adolescence, Adult, Algorithms, Amino Acid Sequence, Animal, Antigen Presentation, Antigens, Surface, IMMUNOLOGY, METABOLISM, Arthritis, Reactive, DRUG THERAPY, IMMUNOLOGY, Autoantigens, IMMUNOLOGY, Autoimmune Diseases, IMMUNOLOGY, Bacterial Outer Membrane Proteins, IMMUNOLOGY, METABOLISM, Borrelia burgdorferi, IMMUNOLOGY, Child, Cross Reactions, Female, Human, HLA-DR Antigens, GENETICS, IMMUNOLOGY, METABOLISM, Immunodominant Epitopes, Lyme Disease, DRUG THERAPY, IMMUNOLOGY, Lymphocyte Function-Associated Antigen-1, CHEMISTRY, IMMUNOLOGY, METABOLISM, Male, Mice, Mice, Transgenic, Molecular Sequence Data, Support, Non-U.S. Gov't, Support, U.S. Gov't, P.H.S., Synovial Fluid, IMMUNOLOGY, T-Lymphocytes, Helper-Inducer, IMMUNOLOGY

Language: Eng

Unique ID: 98350208


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