The Lyme Disease Network
Medical / Scientific Abstract


Title:Genomic sequence of a Lyme disease spirochaete, Borrelia burgdorferi [see comments]
Authors:Fraser CM, Casjens S, Huang WM, Sutton GG, Clayton R, Lathigra R, White O, Ketchum KA, Dodson R, Hickey EK, Gwinn M, Dougherty B, Tomb JF, Fleischmann RD, Richardson D, Peterson J, Kerlavage AR, Quackenbush J, Salzberg S, Hanson M, van Vugt R, Palmer N, Adams MD, Gocayne J, Venter JC, et al
Source:Nature 1997 Dec 11;390(6660):580-6
Organization:The Institute for Genomic Research, Rockville, Maryland 20850, USA.

Abstract:
The genome of the bacterium Borrelia burgdorferi B31, the aetiologic agent of Lyme disease, contains a linear chromosome of 910,725 base pairs and at least 17 linear and circular plasmids with a combined size of more than 533,000 base pairs. The chromosome contains 853 genes encoding a basic set of proteins for DNA replication, transcription, translation, solute transport and energy metabolism, but, like Mycoplasma genitalium, it contains no genes for cellular biosynthetic reactions. Because B. burgdorferi and M. genitalium are distantly related eubacteria, we suggest that their limited metabolic capacities reflect convergent evolution by gene loss from more metabolically competent progenitors. Of 430 genes on 11 plasmids, most have no known biological function; 39% of plasmid genes are paralogues that form 47 gene families. The biological significance of the multiple plasmid-encoded genes is not clear, although they may be involved in antigenic variation or immune evasion.

Keywords:
Biological Transport, Borrelia burgdorferi, GENETICS, Chemotaxis, Chromosomes, Bacterial, DNA Repair, DNA, Bacterial, BIOSYNTHESIS, GENETICS, Energy Metabolism, Gene Expression Regulation, Bacterial, Genome, Bacterial, Lyme Disease, MICROBIOLOGY, Membrane Proteins, GENETICS, Molecular Sequence Data, Plasmids, Recombination, Genetic, Replication Origin, Support, Non-U.S. Gov't, Telomere, Transcription, Genetic, Translation, Genetic

Language: Eng

Unique ID: 98065943


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