The Lyme Disease Network
Medical / Scientific Abstract
|Title:||Immune evasion by tickborne and host-adapted Borrelia burgdorferi.|
|Authors:||de Silva AM, Fikrig E, Hodzic E, Kantor FS, Telford SR 3rd, Barthold SW|
|Source:||J Infect Dis 1998 Feb;177(2):395-400|
JID Home Page: http://www.journals.uchicago.edu/JID/home.html
|Organization:||Center for Comparative Medicine, School of Medicine, University of California, Davis 95616, USA.|
Immune sera from mice infected with the Lyme disease spirochete, Borrelia burgdorferi, have strong biologic activity against spirochetes cultured in vitro. Recent studies with rodents and ticks infected with B. burgdorferi indicate that spirochetes undergo major changes in protein expression as they adapt to the diverse environments encountered by a vectorborne pathogen. The purpose of this study was to explore the susceptibility of three different adaptive forms of B. burgdorferi (in vitro cultured, host-derived, and tickborne) to immune sera. Passive transfer of immune sera protected mice when they were challenged with spirochetes cultured in vitro. Immune sera did not protect mice from tickborne spirochetes or spirochetes derived from infected mice. These results indicate that spirochetes that have adapted within either the feeding tick or host are relatively invulnerable to the protective effects of immune sera, unlike spirochetes grown in vitro, which are highly susceptible.
Animal, Antibodies, Bacterial, ANALYSIS, IMMUNOLOGY, Borrelia burgdorferi, GROWTH & DEVELOPMENT, IMMUNOLOGY, Host-Parasite Relations, IMMUNOLOGY, Immunization, Passive, Ixodes, MICROBIOLOGY, Lyme Disease, IMMUNOLOGY, Mice, Mice, Inbred C3H, Specific Pathogen-Free Organisms, Support, Non-U.S. Gov't, Support, U.S. Gov't, P.H.S.
Unique ID: 98126003
The Lyme Disease Network of NJ, Inc.
43 Winton Road
East Brunswick, NJ 08816