The Lyme Disease Network
Medical / Scientific Abstract

Title:Does process-specific slowing account for cognitive deficits in Lyme disease?
Authors:Pollina DA, Elkins LE, Squires NK, Scheffer SR, Krupp LB
Source:Appl Neuropsychol 1999;6(1):27-32
Organization:Department of Neurology, State University of New York at Stony Brook 11794-8121, USA.

Although several studies have suggested that cognitive slowing is a symptom in Lyme disease, it is not clear whether this slowing is general or relates to specific cognitive tasks. This study examined cognitive speed in 25 Lyme disease patients using a mental arithmetic task. These patients showed significant impairments when initiating the cognitive processes involved in counting, but performed as well as healthy participants (n = 23) when the number of counting increments increased. Lyme patients also performed a speeded perceptual-motor matching task as well as healthy participants. Lyme-related initiation speed deficits were significantly correlated with performance on standardized neuropsychological tests, including the Trail Making Test and the Digit Symbol Test, but not with self-reported depression. These results suggest that the cognitive deficits seen on speeded tasks
are process specific in the Lyme patient group, and are not the result of generalized slowing.

Adult, Borrelia Infections, BLOOD, IMMUNOLOGY, Cognition Disorders, DIAGNOSIS, ETIOLOGY, Female, Human, Lyme Disease, COMPLICATIONS, IMMUNOLOGY, Male, Neuropsychological Tests, Reaction Time, Severity of Illness Index, Time Factors

Language: Eng

Unique ID: 99311577

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