The Lyme Disease Network
Medical / Scientific Abstract


Title:Does process-specific slowing account for cognitive deficits in Lyme disease?
Authors:Pollina DA, Elkins LE, Squires NK, Scheffer SR, Krupp LB
Source:Appl Neuropsychol 1999;6(1):27-32
Organization:Department of Neurology, State University of New York at Stony Brook 11794-8121, USA.

Abstract:
Although several studies have suggested that cognitive slowing is a symptom in Lyme disease, it is not clear whether this slowing is general or relates to specific cognitive tasks. This study examined cognitive speed in 25 Lyme disease patients using a mental arithmetic task. These patients showed significant impairments when initiating the cognitive processes involved in counting, but performed as well as healthy participants (n = 23) when the number of counting increments increased. Lyme patients also performed a speeded perceptual-motor matching task as well as healthy participants. Lyme-related initiation speed deficits were significantly correlated with performance on standardized neuropsychological tests, including the Trail Making Test and the Digit Symbol Test, but not with self-reported depression. These results suggest that the cognitive deficits seen on speeded tasks
are process specific in the Lyme patient group, and are not the result of generalized slowing.

Keywords:
Adult, Borrelia Infections, BLOOD, IMMUNOLOGY, Cognition Disorders, DIAGNOSIS, ETIOLOGY, Female, Human, Lyme Disease, COMPLICATIONS, IMMUNOLOGY, Male, Neuropsychological Tests, Reaction Time, Severity of Illness Index, Time Factors

Language: Eng

Unique ID: 99311577


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