The Lyme Disease Network
Medical / Scientific Abstract


Title:Analysis of antibody response to invariable regions of VlsE, the variable surface antigen of Borrelia burgdorferi.
Authors:Liang FT, Philipp MT
Source:Infect Immun 1999 Dec;67(12):6702-6
Organization:Department of Parasitology, Tulane Regional Primate Research Center, Tulane University Medical Center, Covington, Louisiana 70433, USA.

Abstract:
VlsE, the variable surface antigen of Borrelia burgdorferi, consists of two invariable domains at the amino and carboxyl termini and one central variable domain. The latter contains six invariable regions, IR(1) to IR(6), and six variable regions. In the present study, the antigenicity of all of the invariable regions in B. burgdorferi-infected monkeys, humans, and mice was assessed by peptide-based enzyme-linked immunosorbent assays. Only one invariable region, IR(6), was antigenic in all animals of the three host species. IR(2) and IR(4) were also antigenic in mice.

Keywords:
Amino Acid Sequence, Animal, Antibodies, Bacterial, BIOSYNTHESIS, BLOOD, Antigenic Variation, Antigens, Bacterial, CHEMISTRY, IMMUNOLOGY, Antigens, Surface, CHEMISTRY, IMMUNOLOGY, Borrelia burgdorferi, IMMUNOLOGY, Enzyme-Linked Immunosorbent Assay, METHODS, Human, Lipoproteins, CHEMISTRY, IMMUNOLOGY, Lyme Disease, IMMUNOLOGY, Macaca mulatta, Mice, Mice, Inbred C3H, Molecular Sequence Data, Support, U.S. Gov't, P.H.S.

Language: Eng

Unique ID: 20038343


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