The Lyme Disease Network
Medical / Scientific Abstract
|Title:||Musculoskeletal and neurologic outcomes in patients with previously treated Lyme disease.|
|Authors:||Shadick NA, Phillips CB, Sangha O, Logigian EL, Kaplan RF, Wright EA, Fossel AH, Fossel K, Berardi V, Lew RA, Liang MH|
|Source:||Ann Intern Med 1999 Dec 21;131(12):919-26|
|Organization:||Harvard Medical School and Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.|
BACKGROUND: Previous follow-up studies of patients with Lyme disease suggest that disseminated infection may be associated with long-term neurologic and musculoskeletal morbidity. OBJECTIVE: To determine clinical and functional outcomes in persons who were treated for Lyme disease in the late 1980s. DESIGN: Population-based, retrospective cohort study. SETTING: Nantucket Island, Massachusetts. PARTICIPANTS: 186 persons who had a history of Lyme disease (case-patients) and 167 persons who did not (controls). MEASUREMENTS: Standardized medical history, physical examination, functional status measure (Medical Outcomes Study 36-item Short Form Health Survey [SF-36]), mood state assessment (Profile of Mood States), neurocognitive tests, and serologic examination. RESULTS: The prevalence of Lyme disease among adults on Nantucket Island was estimated to be 14.3% (95% CI, 9.3% to 19.1%). In multivariate analyses, persons with previous Lyme disease (mean time from infection to study evaluation, 6.0 years) had more joint pain (odds ratio for having joint pain in any joint, 2.1 [CI, 1.2 to 3.5]; P = 0.007), more symptoms of memory impairment (odds ratio for having any memory problem, 1.9 [CI, 1.1 to 3.5]; P = 0.003), and poorer functional status due to pain (odds ratio for 1 point on the SF-36 scale, 1.02 [CI, 1.01 to 1.03]; P < 0.001) than persons without previous Lyme disease. However, on physical examination, case-patients and controls did not differ in musculoskeletal abnormalities, neurologic abnormalities, or neurocognitive performance. Persons with previous Lyme disease who had persistent symptoms after receiving treatment (n = 67) were more likely than those who had completely recovered to have had fever, headache, photosensitivity, or neck stiffness during their acute illness (87% compared with 13%; odds ratio, 2.4 [CI, 1.0 to 5.5]; P = 0.045); however, the performance of the two groups on neurocognitive tests did not significantly differ. CONCLUSIONS: Because persons with previous Lyme disease exhibited no sequelae on physical examination and neurocognitive tests a mean of 6.0 years after infection, musculoskeletal and neurocognitive outcomes seem to be favorable. However, long-term impairment of functional status can occur.
Adult, Arthralgia, ETIOLOGY, Fatigue, ETIOLOGY, Female, Follow-Up Studies, Human, Lyme Disease, CLASSIFICATION, COMPLICATIONS, EPIDEMIOLOGY, Male, Massachusetts, EPIDEMIOLOGY, Memory Disorders, ETIOLOGY, Middle Age, Multivariate Analysis, Musculoskeletal Diseases, ETIOLOGY, Nervous System Diseases, ETIOLOGY, Outcome Assessment (Health Care), Prevalence, Retrospective Studies, Support, Non-U.S. Gov't, Support, U.S. Gov't, P.H.S.
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