The Lyme Disease Network
Medical / Scientific Abstract


Title:Effects of OspA vaccination on Lyme disease serologic testing.
Authors:Aguero-Rosenfeld ME, Roberge J, Carbonaro CA, Nowakowski J, Nadelman RB, Wormser GP
Source:J Clin Microbiol 1999 Nov;37(11):3718-21
Organization:Department of Pathology, Department of Medicine, New York Medical College, Valhalla, New York 10595, USA. maria_aguero-rosenfeld@nymc.edu

Abstract:
This study presents the effects of OspA vaccination on two-step testing for Borrelia burgdorferi antibodies. Although vaccinees developed enzyme-linked immunosorbent assay reactivity, immunoblots did not fulfill Centers for Disease Control and Prevention criteria for positivity. Furthermore, OspA reactivity did not interfere with interpretation of immunoblots with sera from patients who developed early Lyme disease despite vaccination.

Keywords:
Adult, Antibodies, Bacterial, BLOOD, Antigens, Surface, IMMUNOLOGY, Bacterial Outer Membrane Proteins, IMMUNOLOGY, Bacterial Vaccines, PHARMACOLOGY, Borrelia burgdorferi, IMMUNOLOGY, Enzyme-Linked Immunosorbent Assay, Human, IgG, BLOOD, IgM, BLOOD, Immunoblotting, Lyme Disease, DIAGNOSIS, IMMUNOLOGY, PREVENTION & CONTROL, Serologic Tests, Vaccination

Language: Eng

Unique ID: 99454877


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