The Lyme Disease Network
Medical / Scientific Abstract


Title:Animal models of Lyme disease: pathogenesis and immunoprophylaxis.
Authors:Philipp MT, Johnson BJ
Source:Trends Microbiol 1994 Nov;2(11):431-7
Organization:Tulane University Medical Center, Tulane Regional Primate Research Center, Covington, LA 70433.

Abstract:
Valuable insights into the pathogenesis and immunoprophylaxis of Lyme disease are beginning to emerge from studies in animal models. This review highlights two animal models: the mouse, which has allowed us to investigate the role of both the immune response and spirochete phenotype in determining the outcome of the disease; and the Rhesus monkey, which manifests signs of nerve involvement, in addition to showing erythema migrans and arthritis.

Keywords:
Animal, Bacterial Vaccines, ADMINISTRATION & DOSAGE, Borrelia burgdorferi, PATHOGENICITY, Consumer Product Safety, Disease Models, Animal, Human, Lyme Disease, IMMUNOLOGY, MICROBIOLOGY, PATHOLOGY, PREVENTION &, CONTROL, Macaca mulatta, Mice, Mice, Inbred C3H, Treatment Outcome

Language: Eng

Unique ID: 95171065


The Lyme Disease Network of NJ, Inc.
43 Winton Road
East Brunswick, NJ 08816
http://www.lymenet.org/