The Lyme Disease Network
Medical / Scientific Abstract


Title:Detection of Borrelia burgdorferi antigens in cerebrospinal fluid.
Authors:Coyle PK, Deng Z, Schutzer SE, Belman AL, Benach J, Krupp LB, Luft B
Source:Neurology 1993 Jun;43(6):1093-8
Organization:Department of Neurology, SUNY at Stony Brook 11794.

Abstract:
We examined CSF for Borrelia burgdorferi antigens using antigen-capture ELISA and Western (immuno) blot. Antigen-capture ELISA was positive in 38 of 77 (49%) CSF samples obtained from neurologic patients with presumed B burgdorferi infection, compared with one of 34 (3%) CSF samples obtained from other neurologic disease controls who came from a region endemic for Lyme disease. Western immunoblot was positive for B burgdorferi antigens in 12 of 22 (55%) CSF samples from the B burgdorferi infected groups, compared with none of 11 CSF samples from the control group. CSF antigen detection should prove helpful in evaluating patients for suspected neurologic Lyme disease.

Keywords:
Adolescence, Adult, Aged, Aged, 80 and over, Antigens, Bacterial, CEREBROSPINAL FLUID, Blotting, Western, Borrelia burgdorferi, IMMUNOLOGY, Child, Child, Preschool, Enzyme-Linked Immunosorbent Assay, Female, Human, Lyme Disease, CEREBROSPINAL FLUID, Male, Middle Age, Sensitivity and Specificity, Support, Non-U.S. Gov't, Support, U.S. Gov't, P.H.S.

Language: Eng

Unique ID: 94224329


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